Introduction to Mutations

Now that we have gone through translation in a lot of detail.  Lets see what happens when something goes WRONG (in ANY of the processes we have learned about this chapter - DNA Replication, Transcription or Translation).  To introduce this topic I had you guys predict the outcomes with the following Daily Questions.

Thursday April 19^th

Using your codon chart – translate the following mRNA sequence

AUG CCA UAC CGC CGG UUU

   Met – Pro – Tyr – Arg – Arg - Phe

What would happen if the following letter changed?

AUG CCG UAC CGC CGG UUU

Met – Pro – Tyr- Arg – Arg – Phe

 The amino acid sequence remained the same – “Silent” mutation.

AUG CCA UAC CGC CAG UUU

Met – Pro – Tyr – Arg – Gin – Phe

“Missense” mutation

AUG CCA UAG CGC CGG UUU

Met – Pro - STOP

“NonSense” mutation

I then had you start working on a project where each of you got a different type of mutation.  You will be making a couple slides describing your mutation, what its effect is on the mRNA and ultimately what effect it has on the amino acid sequence